Targeting the Tumour Microenvironment to Enhance Immunotherapy Against Cancer

Enterotoxins can support CAR T cells against solid tumors

B Von Scheidt, M Wang, AJ Oliver, JD Chan, MK Jana, AI Ali, F Clow, JD Fraser, KM Quinn, PK Darcy, MH Kershaw, CY Slaney

2019-12-10

Responses of solid tumors to chimeric antigen receptor (CAR) T cell therapy are often minimal. This is potentially due to a lack o..

Tissue-specific tumor microenvironments influence responses to immunotherapies

AJ Oliver, AS Davey, SP Keam, S Mardiana, JD Chan, B von Scheidt, PA Beavis, IG House, JRM Van Audernaerde, PK Darcy, MH Kershaw, CY Slaney

2019-01-01

Objectives: Investigation of variable response rates to cancer immunotherapies has exposed the immunosuppressive tumor microenviro..

CARs versus biTEs: A comparison between T cell–redirection strategies for cancer treatment

CY Slaney, P Wang, PK Darcy, MH Kershaw

2018-08-01

The redirection of T cells against tumors holds much promise for the treatment of cancer. Two main approaches for T-cell redirecti..

Tissue-dependent tumor microenvironments and their impact on immunotherapy responses

AJ Oliver, PKH Lau, AS Unsworth, S Loi, PK Darcy, MH Kershaw, CY Slaney

2018-01-31

Recent advances in cancer immunology have led to a better understanding of the role of the tumor microenvironment (TME) in tumor i..